Deebo Samuel and Trent Williams are both questionable for the 49ers

On Friday, the San Francisco 49ers faced mixed injury updates ahead of their upcoming game against the New England Patriots. Star receiver Deebo Samuel, who had been dealing with a calf injury sustained in Week 2, practiced for the second consecutive day and was listed as questionable for the game. In contrast, All-Pro left tackle Trent Williams did not participate in practice due to a sore toe, which he reported after the previous day's session. Coach Kyle Shanahan noted that Williams' condition worsened during practice, leading to his absence on Friday. Tight end George Kittle, who missed the previous game due to a hamstring injury, was cleared for participation without any injury designation. Meanwhile, running back Christian McCaffrey returned from Germany, where he received treatment for Achilles tendinitis. Although he is expected to ramp up his rehabilitation next week, he will remain on injured reserve for at least two more games. In addition to these key players, the team reported other injuries from Thursday's practice. Safety Talanoa Hufanga rolled his ankle and is now listed as questionable, while linebacker Curtis Robinson suffered a torn ACL, ruling him out for the remainder of the season. Linebacker Dee Winters and defensive lineman Jordan Elliott are also dealing with injuries and are considered questionable for the game. The 49ers are navigating a challenging injury landscape as they prepare for their matchup, which could significantly impact their performance and strategy against the Patriots.