Labradors and humans share obesity gene, study reveals

In a recent study conducted by scientists at the University of Cambridge, researchers discovered that Labradors and humans share multiple genes associated with obesity. The study identified DENND1B as the gene most strongly linked with obesity in Labradors, which is also carried by humans and similarly associated with obesity in people. This gene directly influences a brain pathway responsible for regulating energy balance in the body. Along with DENND1B, four additional genes associated with canine obesity were identified, which are also present in humans but with lesser impact on obesity risk. The researchers measured dog behaviors by observing how much they begged for food and their fussy eating habits. They found dogs at high genetic risk of obesity displayed increased appetite, a pattern that parallels findings for people with a high genetic risk of obesity. Even with a genetic predisposition, dog owners who closely monitored their pets’ diets and exercise could prevent their overweight dogs from becoming obese, though it required more attention and effort. The findings suggest a significant correlation between genetic factors and obesity risk for both Labradors and humans. The study emphasizes the importance of management in preventing obesity despite genetic predispositions. It indicates that having a high genetic risk for obesity does not guarantee that an individual—whether canine or human—will become obese, provided they make conscious efforts to manage their weight through a controlled diet and physical activity. Dr. Eleanor Raffan, who led the study published in the journal Science, pointed out that this research reveals critical insights into obesity management. It conveys that individuals with a genetic predisposition to obesity, both dogs and humans, are at a higher risk of overeating when food is readily available. This knowledge can aid in implementing better strategies for pet care and addressing obesity in humans by highlighting the need for conscious dietary choices and regular exercise.