Mayo Clinic Discovers New Type of Memory Loss Similar to Alzheimer's

Scientists at the Mayo Clinic in Minnesota have discovered a new type of memory loss known as Limbic-predominant amnestic neurodegenerative syndrome (LANS). This condition primarily affects the brain's limbic system, which is crucial for regulating emotions and behavior. Unlike Alzheimer’s disease, LANS progresses more slowly and has a more favorable prognosis, as detailed in a recent press release from the clinic. The research team analyzed data from over 200 patients involved in various studies, including the Mayo Clinic Alzheimer's Disease Research Center. They established diagnostic criteria for LANS, which were published in the journal *Brain Communications*. Dr. David T. Jones, a neurologist at Mayo Clinic and the study's senior author, emphasized that prior to this research, diagnosing LANS required post-mortem brain tissue analysis. He noted that many patients exhibit memory loss symptoms that are often misdiagnosed as Alzheimer’s disease. Dr. Jones highlighted that LANS symptoms are typically confined to memory issues and do not extend to other cognitive functions, leading to a better prognosis compared to Alzheimer’s. The researchers aim to leverage these findings to develop personalized therapies for LANS patients, enhancing their management of cognitive symptoms. Rebecca M. Edelmayer, PhD, from the Alzheimer's Association, praised the study, underscoring the importance of establishing objective diagnostic criteria for dementia types. She expressed hope that biomarkers will eventually aid in differentiating between dementia forms, while the new clinical criteria will enable a more tailored approach to patient care.