Christina Applegate Opens Up About Multiple Sclerosis Struggles

In a candid discussion on her MeSsy podcast, actress Christina Applegate shared the profound physical toll that multiple sclerosis (MS) has taken on her since her diagnosis in 2021. The 52-year-old described her condition, likening herself to "Humpty Dumpty" due to significant muscle atrophy in her legs and noticeable weight gain. Applegate expressed her struggles with mobility, stating, "I have no muscles in my legs," and highlighted her transition to a more home-centered lifestyle as a result of her illness. Applegate's limitations have led her to embrace a more sedentary existence, where she finds comfort in her home. "I like being home now because, well, I like being in my bed," she explained, while also acknowledging the joy she feels when she does venture out. To manage her social life, she has begun to set expectations with friends, clarifying that outings will not involve strenuous activities like hiking. Co-host Jamie-Lynn Sigler, who also lives with MS, shared her own experiences, reflecting on her previously active lifestyle before her diagnosis at age 20. The two women connected over their shared challenges, which inspired the creation of their podcast aimed at raising awareness and fostering community among those affected by serious illnesses. Applegate publicly revealed her MS diagnosis in August 2021, shortly after receiving the news from her doctor. The chronic disease affects the central nervous system, and both women are committed to using their platform to support others navigating similar health battles.