New research reveals parental influence on Alzheimer’s inheritance risk

Recent research indicates that the risk of developing Alzheimer’s disease may be influenced by which parent has the condition. A study published on September 13, 2024, highlights that children of mothers diagnosed with Alzheimer’s after age 65 are more likely to exhibit late-onset symptoms themselves. This finding aligns with previous studies that show a correlation between maternal Alzheimer’s and increased beta-amyloid plaque accumulation in the brain, a key indicator of the disease. The research suggests that the X chromosome inherited from mothers may play a significant role in this increased risk. It is theorized that this chromosome could be more susceptible to epigenetic changes, which can activate or deactivate specific genes related to Alzheimer’s. Furthermore, in daughters, the X chromosome from fathers may be silenced, potentially limiting the expression of certain genetic factors that could influence the disease. Additionally, the study raises questions about the inheritance of mitochondrial DNA mutations from mothers, which could also contribute to the risk of Alzheimer’s. However, further research is necessary to fully understand the mechanisms behind these genetic transmissions and their implications for future generations. Overall, the findings underscore the importance of maternal health in the context of Alzheimer’s disease and suggest that genetic factors may vary significantly based on parental lineage. This could lead to new insights into prevention and treatment strategies for Alzheimer’s in families with a history of the disease.