Researchers uncover potential of fermented stevia in cancer treatment

In Japan, scientists at Hiroshima University have made a significant breakthrough in cancer research by exploring the potential anti-cancer properties of fermented stevia. The research indicates that fermented stevia, which is a plant commonly used as a zero-calorie sweetener, might play a crucial role in inhibiting the progression of pancreatic cancer, a disease known for its poor prognosis. Conventional treatments rarely cure this aggressive cancer, leading to survival rates that starkly decline after five years post-diagnosis. With symptoms often emerging only after the disease has advanced, there is an urgent need for alternative treatments. The researchers focused on the fermentation process, employing a specific strain of bacteria, Lactobacillus plantarum SN13T, known for its use in various fermented foods. Their innovative approach sought to identify whether fermentation could amplify the health benefits of stevia. Analysis revealed that a compound termed CAME, resulting from the fermentation process, appears to significantly alter cancer cell genetics, inhibiting their growth and promoting self-destruction. This mechanism represents a promising avenue, as it demonstrates the potential to target cancer cells while leaving healthy ones unharmed, a goal that has remained elusive in cancer therapies. Fermented stevia extract was determined to be a more effective antioxidant compared to unfermented versions, bolstering the overall health effect by neutralizing free radicals more effectively. This discovery supports the idea that fermentation can enhance the bioactive properties of certain plants, as seen previously with fermented soy and ginseng. However, it is essential to note that these findings arise from laboratory studies on cells, and there is a longstanding history of promising compounds failing during clinical trials due to the complexities of human biology. Despite these challenges, the initial results from this research are exciting and warrant further studies to better understand how fermented stevia can be utilized in cancer therapy. Though the findings are in their early stages and much more research is required, they suggest a potentially groundbreaking step in the quest for better treatment options for patients battling pancreatic cancer. If further investigations confirm these results, fermented stevia could become part of a novel approach to combating one of the deadliest forms of cancer.