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In a Thursday Night Football game at Highmark Stadium in Orchard Park, New York, the Buffalo Bills defeated the Detroit Lions 41-31. Quarterback Josh Allen threw three touchdown passes and ran for two more, leading the Bills to a 2-0 record. The Lions, now 1-1, were led by Amon-Ra St. Brown's two touchdown catches. Allen's performance marked his 10th career game with at least two passing and two rushing touchdowns, an NFL record. The Bills scored on their first four possessions and converted 9 of 12 third downs.
