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In Orchard Park, New York, the Buffalo Bills faced the Detroit Lions on Thursday Night Football on September 17, 2026. The Bills announced that starting defensive tackle Ed Oliver was ruled out after injuring his hip during pregame warmups. Oliver, an eight-year starter, was not on the injury report earlier in the week. His absence left the Bills with only four healthy defensive linemen, as rookie T.J. Sanders was also inactive. The Lions were missing starting offensive linemen Blake Miller and Christian Mahogany. Cornerback D.J. Reed was active despite a foot injury. The game was a key early-season matchup between two strong teams.
