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Joe Manganiello says autoimmune illness and marriage strain with Sofía Vergara are detailed in his memoir Bloodlines
Joe Manganiello, an American actor, has revealed in his upcoming memoir Bloodlines that he suffered from a severe autoimmune illness for seven years, beginning shortly after his 2015 marriage to Sofía Vergara. The illness caused significant weight loss, multiple surgeries, and reliance on pain medication, which conflicted with his sobriety. He claims the health struggles and disagreements about having children contributed to their divorce in 2023. Vergara has said the split was due to their different views on having kids, but Manganiello disputes this. The memoir details his physical and emotional journey, including suicidal thoughts and his eventual recovery.

Updated Oct 8, 2026 First reported Oct 7, 2026